Trayectory

Study Protocol

A safety and efficacy extension study of pertuzumab in patients with solid tumors previously enrolled in a Hoffmann-La Roche sponsored clinical trial of pertuzumab.

Study Protocol

A phase II A open-label study in infants with respiratory syncytial virus lower respiratory tract infection, followed by a double-blind, placebo-controlled trial to evaluate the safety, tolerability, pharmacokinetics, and antiviral effect of rv521.

Study Protocol

An efficacy, safety, tolerability, and pharmacokinetics study of tofacitinib for treating Systemic Juvenile Idiopathic Arthritis (SJIA) with active systemic features in children and adolescents.

Study Protocol

A long-term open-label follow-up study of tofacitinib for treating Juvenile Idiopathic Arthritis (JIA).

Study Protocol

A bench test study on Ergonomix® round and round plus breast implants with the micro-transponder to determine if a gel fracture affects the ability of Magnetic Resonance Imaging (MRI) to detect an implant rupture.

Study Protocol

A preliminary radiotherapy study to evaluate the effects of the flora tissue expander on radiation planning and dosages.

Study Protocol

A randomized, double-blind, phase III study of pembrolizumab versus placebo in combination with neoadjuvant chemotherapy and adjuvant endocrine therapy for the treatment of high-risk early-stage estrogen receptor-positive, human epidermal growth factor of receptor 2 negative (er+ /her2-) breast cancer (keynote-756).

Study Protocol

A randomized, open-label, multicenter Phase III study evaluating the efficacy and safety of adjuvant giredestrant compared to physician's choice of endocrine adjuvant monotherapy in patients with estrogen receptor-positive, her2-negative (her2-) early breast cancer.

Study Protocol

A Randomized, open-label, multicenter Phase III study evaluating the efficacy and safety of adjuvant giredestrant compared to physician's choice of endocrine adjuvant monotherapy in patients with estrogen receptor-positive, her2-negative (her2-) early breast cancer.

Study Protocol

A phase III, randomized, open-label, multicenter, open-label study evaluating the efficacy and safety of adjuvant giredestrant compared to physician-choice adjuvant endocrine monotherapy in patients with estrogen receptor-positive, her2-negative (her2-) early breast cancer.

Study Protocol

PARC (by its Spanish acronym) – High Risk Cancer Program.

Study Protocol

Study of duplication of outcomes for early diagnosis of lung cancer. Observational patient registry study to collect real-world evidence (RWE) on managing pulmonary nodules in Latin America.

STUDY PROTOCOL

A single-arm phase II study of atezolizumab in patients with locally advanced cancer who have not progressed after concurrent platinum-based chemo-radiation.

Study Protocol

A study of exacerbations and their international outcomes (Exacos Internacional) that studies the understanding of the burden of severe exacerbations of Chronic Obstructive Pulmonary Disease (COPD) and the relationship between the frequency of severe exacerbations and clinical and healthcare utilization outcomes in less-resourced countries.

Study protocol

A safety, efficacy, and pharmacokinetic (PK) study of vibostolimab (mk-7684), as monotherapy, in combination with pembrolizumab (mk-3475) or pembrolizumab plus pemetrexed and carboplatin in adults with solid metastatic tumors..

Study protocol

A randomized Phase III study evaluating the efficacy and safety of lenvatinib (e7080/mk-7902) in conjunction with pembrolizumab (mk-3475) plus chemotherapy compared to standard of care therapy as a first-line intervention in participants with Advanced/Metastatic Gastroesophageal Adenocarcinoma (leap-015).

Study protocol

A Phase III B, multinational, multicenter, randomized, open-label, Phase III B study that evaluates patient preference for home administration of a fixed-dose combination of pertuzumab and trastuzumab subcutaneously in participants with early or locally advanced/inflammatory her2-positive (her2+) breast cancer.

Study protocol

Phase 2, multicenter, multiarm study to evaluate MK-1308A (coformulation of quavonlimab (MK-1308) with pembrolizumab) versus other treatments in participants with high microsatellite instability (MSI-H) stage IV colorectal cancer or with impaired repair pathway (dMMR): (MK-1308A-008).

Study protocol

Bench trial study on Round Ergonomix® and Round microtransponder breast implants to determine if a fracture in the gel affects the ability of an MRI to demonstrate implant rupture.

Study protocol

A Randomized, Multicenter, Placebo-Controlled, Phase 2b Study of BPZE1 Intranasal Pertussis Vaccine in Healthy School-Aged Children, to Evaluate the Immune Response and Safety Profile of a Single Dose of BPZE1 With and Without Co-administration of Tetanus, diphtheria and acellular pertussis (Boostrix™) IB-201P.